Treatment of psoriatic nails with tazarotene cream 0.1% vs. clobetasol propionate 0.05% cream: a double-blind study.

Sir, Nail psoriasis affects 20–55% of psoriatic patients. It often represents a significant cause of distress because of the visible lesions and the chronic course of the disease. Treatment options include corticosteroids, vitamin D3 analogues, 5-fluorouracil, urea, anthralin, cyclosporine and radiotherapy (1). Tazarotene is an acetylenic retinoid with documented therapeutic results in skin psoriasis. The therapeutic potential of tazarotene 0.1% gel in nail psoriasis has been evaluated in one open-label study (2) and one placebocontrolled study (3) with promising results. The objective of this double-blind study was to compare the efficacy of tazarotene 0.1% cream with clobetasol propionate 0.05% cream in nail psoriasis.